Module 4
Reduction and Refinement in Scientific Research
Competency:
Apply the principles of reduction and refinement to animal testing
Learning Objectives:
- Define the 3Rs Principles of replacement and refinement
- Describe the benefits of reducing the number of animals used in research
- Identify the importance of sample size selection when applying the principle of reduction
- Apply the resource equation to experimental sample size calculations
- Summarize examples of refinement in experimentation
- Describe how refinement can be applied to make experiments more humane in cases where animal use cannot be avoided.
Assessment:
Monkey House Project Case Study
- Apply reduction and refinement to an animal-based drug study design
- Calculate an ideal sample size for the case study design using the resource equation
- Identify ways to refine the experimental design to enhance animal welfare