Module 5
Experimental Design and Reproducibility
Competency:
Critique elements of experimental design and reporting for reproducibility and validity
Learning Objectives:
- Explain the steps of the scientific method
- Describe the characteristics of quality scientific research
- Explain current threats to quality scientific research including lack of reproducibility, faulty experimental design, and pressure to publish
- Describe experimental design factors that impact experiment reproducibility
- Identify reporting factors that impact experimental reproducibility
- Identify steps researchers take to increase the validity of results
- Identify strategies for applying the 3 Rs to improve research design and validity
Assessment:
Case Study: Forced Swim Test
- Identify the control, independent, and dependent variables
- List steps taken to increase the validity of results
- Correlate the study to the 10 essential ARRIVE guidelines
- Identify potential limitations of the experimental design
- Consider data from subsequent human study applications draw conclusions about the effectiveness of the animal study